Charles University operates additional Medical Faculties in Hradec Králové and Plzeň (Pilsen), both offering six-year English-taught General Medicine programmes with a more intimate learning environment than the Prague faculties. The Faculty in Hradec Králové conducts clinical teaching at the University Hospital Hradec Králové — a 1,300-bed facility that is one of the Czech Republic's most advanced, featuring a heliport, burn centre, and cardiac surgery. The Faculty in Plzeň trains at University Hospital Plzeň (1,000+ beds), which serves as the referral centre for western Bohemia.

Both faculties have significantly smaller international cohorts (40-80 per year vs. 200+ in Prague), resulting in more personalised teaching, closer faculty relationships, and guaranteed clinical hands-on time. Hradec Králové is a pleasant university town with excellent amenities and very low living costs, while Plzeň (Pilsen) is famous for its brewing heritage and relaxed lifestyle.

For UK students who prefer a smaller, more supportive environment over big-city life, these faculties offer the same Charles University degree (MUDr.) at slightly lower tuition, with intimate class sizes and genuine community.